Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches

Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches

Group B Streptococcus (GBS) colonizes the gastrointestinal and vaginal epithelium of a significant percentage of healthy women, with potential for ascending intrauterine infection or transmission during parturition, creating a risk of serious disease in the vulnerable newborn. This review highlights new insights on the bacterial virulence determinants, host immune responses, and microbiome inte...

Maternal and neonatal group B streptococcal bacteriuria.

Group B Streptococcal Colonization, Molecular Characteristics, and Epidemiology

Streptococcus agalactiae or group B streptococcus (GBS) is a leading cause of serious neonatal infections. GBS is an opportunistic commensal constituting a part of the intestinal and vaginal physiologic flora and maternal colonization is the principal route of GBS transmission. GBS is a pathobiont that converts from the asymptomatic mucosal carriage state to a major bacterial pathogen causing s...

Prevention of Neonatal Group B Streptococcal Disease

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial Group B streptococci (GBS) are facultative anaerobic, gram-positive cocci that colonize the gastrointestinal and urogenital tracts of humans. GBS strains are serologically divided into 10 types (Ia, Ib, and II through IX) according to their capsula...

Relationship between Colonization of Group B Streptococcal (GBS) in the Reproductive System of Pregnant Women with PCR with Neonatal and Maternal Complications

Background and Aim: Group B Streptococcus (GBS) is a major contributor to maternal and neonatal death. GBS colonization in the mother can be transient or intermittent, which is why its examination during delivery is more valuable than screening at lower gestational age. The aim of this study was to compare the complications of premature delivery with term ones in positive cases of GBS by PCR me...